Publikationen von Winfried Denk

2024

Zeitschriftenartikel

Rickgauer, J. P.; Choi, H.; Moore, A. S.; Denk, W.; Lippincott-Schwartz, J.: Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching. Molecular Cell 84 (24), S. 4912 - 4928.e7 (2024)

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2022

Zeitschriftenartikel

Svara, F. N.; Förster, D.; Kubo, F.; Januszewski, M.; Dal Maschio, M.; Schubert, P. J.; Kornfeld, J.; Wanner, A. A.; Laurell, E.; Denk, W. et al.; Baier, H.: Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain. Nature Methods 19 (11), S. 1357 - 1366 (2022)

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2020

Zeitschriftenartikel

Abbott, L. F.; Bock, D. D.; Callaway, E. M.; Denk, W.; Dulac, C.; Fairhall, A. L.; Fiete, I.; Harris, K. M.; Helmstaedter, M.; Jain, V. et al.; Kasthuri, N.; LeCun, Y.; Lichtman, J. W.; Littlewood, P. B.; Luo, L.; Maunsell, J. H. R.; Reid, R. C.; Rosen, B. R.; Rubin, G. M.; Sejnowski, T. J.; Seung, H. S.; Svoboda, K.; Tank, D. W.; Tsao, D.; Van Essen, D. C.: The mind of a mouse. Cell 182 (6), S. 1372 - 1376 (2020)

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2018

Zeitschriftenartikel

Boergens, K. M.; Kapfer, C.; Helmstaedter, M.; Denk, W.; Borst, A.: Full reconstruction of large lobula plate tangential cells in Drosophila from a 3D EM dataset. PLoS One 13 (11), e0207828 (2018)

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ZIP

Zeitschriftenartikel

Januszewski, M.; Kornfeld, J.; Li, P. H.; Pope, A.; Blakely, T.; Lindsey, L.; Maitin-Shepard, J.; Tyka, M.; Denk, W.; Jain, V.: High-precision automated reconstruction of neurons with flood-filling networks. Nature Methods 15 (8), S. 605 - 610 (2018)

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Zeitschriftenartikel

Kornfeld, J.; Denk, W.: Progress and remaining challenges in high-throughput volume electron microscopy. Current Opinion in Neurobiology 50, S. 261 - 267 (2018)

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Zeitschriftenartikel

Svara, F. N.; Kornfeld, J.; Denk, W.; Bollmann, J. H.: Volume EM reconstruction of spinal cord reveals wiring specificity in speed-related motor circuits. Cell Reports 23 (10), S. 2942 - 2954 (2018)

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supplementary-material

ZIP

2017

Zeitschriftenartikel

Kornfeld, J.; Benezra, S. E.; Narayanan, R. T.; Svara, F. N.; Egger, R.; Oberlaender, M.; Denk, W.; Long, M. A.: EM connectomics reveals axonal target variation in a sequence-generating network. eLife 6, e24364 (2017)

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supplementary-material

Zeitschriftenartikel

Rickgauer, J. P.; Grigorieff, N.; Denk, W.: Single-protein detection in crowded molecular environments in cryo-EM images. eLife 6, e25648 (2017)

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supplementary-material

2015

Zeitschriftenartikel

Mikula, S.; Denk, W.: High-resolution whole-brain staining for electron microscopic circuit reconstruction. Nature Methods 12 (6), S. 541 - 546 (2015)

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2014

Zeitschriftenartikel

Kim, J. S.; Greene, M. J.; Zlateski, A.; Lee, K.; Richardson, M.; Turaga, S. C.; Purcaro, M.; Balkam, M.; Robinson, A.; Behabadi, B. F. et al.; Campos, M.; Denk, W.; Seung, H. S.; EyeWirers: Space-time wiring specificity supports direction selectivity in the retina. Nature 509 (7500), S. 331 - 336 (2014)

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2013

Zeitschriftenartikel

Binding, J.; Mikula, S.; Denk, W.: Low-dosage maximum-a-posteriori focusing and stigmation. Microscopy and Microanalysis 19 (1), S. 38 - 55 (2013)

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Zeitschriftenartikel

Helmchen, F.; Denk, W.; Kerr, J. N.: Miniaturization of two-photon microscopy for imaging in freely moving animals. Cold Spring Harbor Protocols 2013 (10), S. 904 - 913 (2013)

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Zeitschriftenartikel

Helmstaedter, M.; Briggman, K.; Turaga, S. C.; Jain, V.; Seung, H. S.; Denk, W.: Connectomic reconstruction of the inner plexiform layer in the mouse retina. Nature 500 (7461), S. 168 - 174 (2013)

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Zeitschriftenartikel

Titze, B.; Denk, W.: Automated in-chamber specimen coating for serial block-face electron microscopy. Journal of Microscopy 250 (2), S. 101 - 110 (2013)

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2012

Zeitschriftenartikel

Andres, B.; Koethe, U.; Kroeger, T.; Helmstaedter, M.; Briggman, K.; Denk, W.; Hamprecht, F. A.: 3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries. Medical Image Analysis 16 (4), S. 796 - 805 (2012)

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Zeitschriftenartikel

Bargmann, C.; Denk, W.; Graybiel, A.: An interview with...: The Kavli prize winners. Nature Reviews Neuroscience 13 (10), S. 669 - 673 (2012)

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Zeitschriftenartikel

Denk, W.; Briggman, K.; Helmstaedter, M.: Structural neurobiology: Missing link to a mechanistic understanding of neural computation. Nature Reviews Neuroscience 13 (5), S. 351 - 358 (2012)

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Zeitschriftenartikel

Denk, W.; Miesenböck, G.: Neurotechnology: Summa technologiae. Current Opinion in Neurobiology 22 (1), S. 1 - 2 (2012)

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Zeitschriftenartikel

Mikula, S.; Binding, J.; Denk, W.: Staining and embedding the whole mouse brain for electron microscopy. Nature Methods 9 (12), S. 1198 - 1201 (2012)

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2011

Zeitschriftenartikel

Briggman, K.; Helmstaedter, M.; Denk, W.: Wiring specificity in the direction-selectivity circuit of the retina. Nature 471 (7337), S. 183 - 188 (2011)

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Zeitschriftenartikel

Helmstaedter, M.; Briggman, K.; Denk, W.: High-accuracy neurite reconstruction for high-throughput neuroanatomy. Nature Neuroscience 14 (8), S. 1081 - 1088 (2011)

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Zeitschriftenartikel

Kleinfeld, D.; Bharioke, A.; Blinder, P.; Bock, D. D.; Briggman, K.; Chklovskii, D. B.; Denk, W.; Helmstaedter, M.; Kaufhold, J. P.; Lee, W. A. et al.; Meyer, H. S.; Micheva, K. D.; Oberlaender, M.; Prohaska, S.; Reid, R. C.; Smith, S. J.; Takemura, S.; Tsai, P. S.; Sakmann, B.: Large-scale automated histology in the pursuit of connectomes. The Journal of Neuroscience 31 (45), S. 16125 - 16138 (2011)

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Zeitschriftenartikel

Lichtman, J. W.; Denk, W.: The big and the small: Challenges of imaging the brain's circuits. Science 334 (6056), S. 618 - 623 (2011)

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Zeitschriftenartikel

Mittmann, W.; Wallace, D. J.; Czubayko, U.; Herb, J.; Schaefer, A. T.; Looger, L. L.; Denk, W.; Kerr, J. N.: Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo. Nature Neuroscience 14 (8), S. 1089 - 1093 (2011)

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Zeitschriftenartikel

Theer, P.; Denk, W.; Sheves, M.; Lewis, A.; Detwiler, P. B.: Second-harmonic generation imaging of membrane potential with retinal analogues. Biophysical Journal 100 (1), S. 232 - 242 (2011)

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2010

Zeitschriftenartikel

Aguirre, A. D.; Sawinski, J.; Huang, S. W.; Zhou, C.; Denk, W.; Fujimoto, J. G.: High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe. Optics Express 18 (5), S. 4222 - 4239 (2010)

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Zeitschriftenartikel

Turaga, S. C.; Murray, J. F.; Jain, V.; Roth, F.; Helmstaedter, M.; Briggman, K.; Denk, W.; Seung, H. S.: Convolutional networks can learn to generate affinity graphs for image segmentation. Neural computation 22 (2), S. 511 - 538 (2010)

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2009

Zeitschriftenartikel

Euler, T.; Hausselt, S.; Margolis, D. J.; Breuninger, T.; Castell, X.; Detwiler, P. B.; Denk, W.: Eyecup Scope - Optical recordings of light stimulus-evoked fluorescence signals in the retina. Pflügers Archiv: European Journal of Physiology 457 (6), S. 1393 - 1414 (2009)

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Zeitschriftenartikel

Jurrus, E.; Hardy, M.; Tasdizen, T.; Fletcher, P. T.; Koshevoy, P.; Chien, C.; Denk, W.; Whitaker, R.: Axon tracking in serial block-face scanning electron microscopy. Medical Image Analysis 13 (1), S. 180 - 188 (2009)

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Zeitschriftenartikel

Sawinski, J.; Haydon-Wallace, D. J.; Greenberg, D. S.; Grossmann, S.; Denk, W.; Kerr, J. N.: Visually evoked activity in cortical cells imaged in freely moving animals. Proceedings of the National Academy of Sciences of the United States of America 106 (46), S. 19557 - 19562 (2009)

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Zeitschriftenartikel

Yamahachi, H.; Marik, S. A.; McManus, J. N.; Denk, W.; Gilbert, C. D.: Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex. Neuron 64 (5), S. 719 - 729 (2009)

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2008

Zeitschriftenartikel

Helmstaedter, M.; Briggman, K.; Denk, W.: 3D structural imaging of the brain with photons and electrons. Current Opinion in Neurobiology 18 (6), S. 633 - 641 (2008)

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Zeitschriftenartikel

Kerr, J. N.; Denk, W.: Imaging in vivo: Watching the brain in action. Nature Reviews Neuroscience 9 (3), S. 195 - 205 (2008)

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Zeitschriftenartikel

Kitamura, K.; Judkewitz, B.; Kano, M.; Denk, W.; Häusser, M.: Targeted patch−clamp recordings and single−cell electroporation of unlabeled neurons in vivo. Nature Methods 5 (1), S. 61 - 67 (2008)

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Zeitschriftenartikel

Kuhn, B.; Denk, W.; Bruno, R. M.: In vivo two−photon voltage−sensitive dye imaging reveals top−down control of cortical layers 1 and 2 during wakefulness. Proceedings of the National Academy of Sciences of the United States of America 105 (21), S. 7588 - 7593 (2008)

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Zeitschriftenartikel

Macke, J. H.; Maack, N.; Gupta, R.; Denk, W.; Schölkopf, B.; Borst, A.: Contour-propagation algorithms for semi-automated reconstruction of neural processes. Journal of Neuroscience Methods 167 (2), S. 349 - 357 (2008)

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Zeitschriftenartikel

Major, G.; Polsky, A.; Denk, W.; Schiller, J.; Tank, D. W.: Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. Journal of Neurophysiology 99 (5), S. 2584 - 2601 (2008)

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Zeitschriftenartikel

O´Connell, M. K.; Murthy, S.; Phan, S.; Xu, C.; Buchanan, J.; Spilker, R.; Dalman, R. L.; Zarins, C. K.; Denk, W.; Taylor, C. A.: The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging. Matrix Biology 27 (3), S. 171 - 181 (2008)

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Zeitschriftenartikel

Wallace, D. J.; Meyer zum Alten Borgloh, S.; Astori, S.; Yang, Y.; Bausen, M.; Kügler, S.; Palmer, A. E.; Tsien, R. Y.; Sprengel, R.; Kerr, J. N. et al.; Denk, W.; Hasan, M. T.: Single−spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nature Methods 5 (9), S. 797 - 804 (2008)

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2007

Zeitschriftenartikel

Hausselt, S.; Euler, T.; Detwiler, P. B.; Denk, W.: A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells. PLoS Biology 5 (7), 185, S. 1474 - 1493 (2007)

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Zeitschriftenartikel

Rückel, M.; Denk, W.: Properties of coherence-gated wavefront sensing. Journal of the Optical Society of America A 24 (11), S. 3517 - 3529 (2007)

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Zeitschriftenartikel

Sawinski, J.; Denk, W.: Miniature random-access fiber scanner for in vivo multiphoton imaging. Journal of Applied Physics 102 (3), 034701 (2007)

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2006

Zeitschriftenartikel

Briggman, K.; Denk, W.: Towards neural circuit reconstruction with volume electron microscopy techniques. Current Opinion in Neurobiology 16 (5), S. 562 - 570 (2006)

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Zeitschriftenartikel

Komai, S.; Denk, W.; Osten, P.; Brecht, M.; Margrie, T. W.: Two-photon targeted patching (TPTP) in vivo. Nature Protocols 1 (2), S. 648 - U5 (2006)

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Zeitschriftenartikel

Komai, S.; Licznerski, P.; Cetin, A.; Waters, D. J.; Denk, W.; Brecht, M.; Osten, P.: Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience−dependent development. Nature Neuroscience 9 (9), S. 1125 - 1133 (2006)

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Zeitschriftenartikel

Rückel, M.; Mack-Bucher, J. A.; Denk, W.: Adaptive wavefront correction in two−photon microscopy using coherence gated wavefront sensing. Proceedings of the National Academy of Sciences of the United States of America 103 (46), S. 17137 - 17142 (2006)

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Zeitschriftenartikel

Stettler, D. D.; Yamahachi, H.; Li, W.; Denk, W.; Gilbert, C. D.: Axons and synaptic boutons are highly dynamic in adult visual cortex. Neuron 49 (6), S. 877 - 887 (2006)

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Zeitschriftenartikel

Theer, P.; Denk, W.: On the fundamental imaging−depth limit in two−photon microsopy. Journal of the Optical Society of America A 23 (12), S. 3139 - 3149 (2006)

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