Publikationen von Alexander Flügel

Zhang, B.; Watt, J. M.; Cordiglieri, C.; Dammermann, W.; Mahon, M. F.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: Small molecule antagonists of NAADP-induced Ca2+ release in T-lymphocytes suggest potential therapeutic agents for autoimmune disease. Scientific Reports 8, 16775 (2018)

Cordiglieri, C.; Odoardi, F.; Zhang, B.; Nebel, M.; Kawakami, N.; Klinkert, W. E. F.; Lodygin, D.; Luhder, F.; Breunig, E.; Schild, D. et al.; Ulaganathan, V. K.; Dornmair, K.; Dammermann, W.; Potter, B. V. L.; Guse, A. H.; Flügel, A.: Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133, S. 1930 - 1943 (2010)

Kawakami, N.; Flügel, A.: Knocking at the brain's door: Intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Springer Seminars in Immunopathology 32 (3), S. 275 - 287 (2010)

Volovitz, I.; Marmor, Y.; Mor, F.; Fluegel, A.; Odoardi, F.; Eisenbach, L.; Cohen, I. R.: T cell vaccination induces the elimination of EAE effector T cells: Analysis using GFP-transduced, encephalitogenic T cells. Journal of Autoimmunity 35 (2), S. 135 - 144 (2010)

Bartholomäus, I.; Kawakami, N.; Odoardi, F.; Schläger, C.; Miljkovic, D.; Ellwart, J. W.; Klinkert, W. E. F.; Flügel-Koch, C.; Issekutz, T. B.; Wekerle, H. et al.; Flügel, A.: Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 462 (7269), S. 94 - 98 (2009)

Dammermann, W.; Zhang, B.; Nebel, M.; Cordiglieri, C.; Odoardi, F.; Kirchberger, T.; Kawakami, N.; Dowden, J.; Schmid, F.; Dornmair, K. et al.; Hohenegger, M.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America 106 (26), S. 10678 - 10683 (2009)

Matheu, M. P.; Beeton, C.; Garcia, A.; Chi, V.; Rangaraju, S.; Safrina, O.; Monaghan, K.; Uemura, M. I.; Li, D.; Pal, S. et al.; de la Maza, L. M.; Monuki, E.; Flügel, A.; Pennington, M. W.; Parker, I.; Chandy, K. G.; Cahalan, M. D.: Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity 29 (4), S. 602 - 614 (2008)

Müller, N.; van den Brandt, J.; Odoardi, F.; Tischner, D.; Herath, J.; Flügel, A.; Reichardt, H. M.: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats. Journal of Clinical Investigation 118 (4), S. 1405 - 1416 (2008)

Odoardi, F.; Cordiglieri, C.; Dammermann, W.; Zhang, B.; Hohenegger, M.; Potter, B. V.; Guse, A.; Flügel, A.: NAADP/Ca2+ signaling: A new therapeutic target for T cell mediated autoimmune disease. Wiener Klinische Wochenschrift 120 (Suppl. Suppl. 1), S. 54 - 54 (2008)

Rooney, G. E.; Moran, C.; McMahon, S. S.; Ritter, T.; Maenz, M.; Flügel, A.; Dockery, P.; O'Brien, T.; Howard, L.; Windebank, A. J. et al.; Barry, F. P.: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Engineering Part A 14 (5), S. 681 - 690 (2008)

Flügel, A.; Odoardi, F.; Nosov, M.; Kawakami, N.: Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. Journal of Neuroimmunology 191 (1-2), S. 86 - 97 (2007)

Gong, N.; Pleyer, U.; Vogt, K.; Anegon, I.; Flügel, A.; Volk, H.-D.; Ritter, T.: Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival. Investigative Ophthalmology and Visual Science 48 (3), S. 1043 - 1052 (2007)

Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), S. 261 - 275 (2007)

Odoardi, F.; Kawakami, N.; Klinkert, W. E. F.; Wekerle, H.; Flügel, A.: Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America 104 (47), S. 18625 - 18630 (2007)

Odoardi, F.; Kawakami, N.; Li, Z. X.; Cordiglieri, C.; Streyl, K.; Nosov, M.; Klinkert, W. E. F.; Ellwart, J. W.; Bauer, J.; Lassmann, H. et al.; Wekerle, H.; Flügel, A.: Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 104 (3), S. 920 - 925 (2007)

Kirchberger, T.; Wagner, G.; Xu, J.; Cordiglieri, C.; Wang, P.; Gasser, A.; Fliegert, R.; Bruhn, S.; Flügel, A.; Lund, F. E. et al.; Zhang, L. H.; Potter, B. V. L.; Guse, A. H.: Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. British Journal of Pharmacology 149 (4), S. 337 - 344 (2006)

Bradl, M.; Bauer, J.; Flügel, A.; Wekerle, H.; Lassmann, H.: Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. American Journal of Pathology 166 (5), S. 1441 - 1450 (2005)

Kawakami, N.; Nägerl, U. V.; Odoardi, F.; Bonhoeffer, T.; Wekerle, H.; Flügel, A.: Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. Journal of Experimental Medicine 201 (11), S. 1805 - 1814 (2005)

Kawakami, N.; Odoardi, F.; Ziemssen, T.; Bradl, M.; Ritter, T.; Neuhaus, O.; Lassmann, H.; Wekerle, H.; Flügel, A.: Autoimmune CD4(+) T cell memory: Lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. Journal of Immunology 175 (1), S. 69 - 81 (2005)

Aboul-Enein, F.; Bauer, J.; Klein, M.; Schubart, A.; Flügel, A.; Ritter, T.; Kawakami, N.; Siedler, F.; Linington, C.; Wekerle, H. et al.; Lassmann, H.; Bradl, M.: Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation. Journal of Neuropathology and Experimental Neurology 63 (12), S. 1284 - 1296 (2004)

Kawakami, N.; Lassmann, S.; Li, Z. X.; Odoardi, F.; Ritter, T.; Ziemssen, T.; Klinkert, W. E. F.; Ellwart, J. W.; Bradl, M.; Krivacic, K. et al.; Lassmann, H.; Ransohoff, R. M.; Volk, H. D.; Wekerle, H.; Linington, C.; Flügel, A.: The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Journal of Experimental Medicine 199 (2), S. 185 - 197 (2004)

Kawakami, N.; Nägerl, U. V.; Wekerle, H.; Flügel, A.: Live-imaging of encephalitogenic T lymphocytes in the living target tissue. Journal of Neuroimmunology 154 (1-2 Sp. Iss. Sp. Iss. SI), S. 224 - 224 (2004)

Thurau, S. R.; Mempel, T. R.; Flügel, A.; Diedrichs-Moehring, M.; Krombach, F.; Kawakami, N.; Wildner, G.: The fate of autoreactive, GFP(+) T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS. International Immunology 16 (11), S. 1573 - 1582 (2004)

Bradl, M.; Flügel, A.: The role of T cells in brain pathology. Curr Top Microbiol Immunol. 265, S. 141 - 162 (2002)

Hammer, M. H.; Schroder, G.; Risch, K.; Flügel, A.; Volk, H. D.; Lehmann, M.; Ritter, T.: Antigen-dependent transgene expression in kidney transplantation: A novel approach using gene-engineered T lymphocytes. Journal of the American Society of Nephrology 13 (2), S. 511 - 518 (2002)

Flügel, A.; Bradl, M.; Kreutzberg, G. W.; Graeber, M. B.: Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. Journal of Neuroscience Research 66 (1), S. 74 - 82 (2001)

Wekerle, H.; Flügel, A.: Demyelinating diseases: Immunological mechanisms in the pathogenesis of multiple Sclerosis. In: Molecular Neurology, S. 475 - 497 (Hg. Waxman, S. G.). Elsevier (2007)

Flügel, A.: Gentransfer in Antigen-spezifischen CD4+ T-Zellen: Schicksal und Funktion autoreaktiver T-Zellen im Organismus. Habilitation, Ludwig-Maximilians-Universität, München (2004)

Graeber, M. B.; Banati, R. B.; Flügel, A.; Streit, W. J.; Tetzlaff, W.: Courage, luck and patience: In celebration of the 80th birthday of Georg W. Kreutzberg. Acta Neuropathologica 124, S. 593 - 598 (2012)