Publikationen von Hartmut Wekerle

Zeitschriftenartikel (103)

2025
Zeitschriftenartikel
Wekerle, H.; Kawakami, N.: Brain myelin trains T cells to stop autoimmunity. Nature 637 (8044), S. 41 - 42 (2025)
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Yoon, H.; Gerdes, L. A.; Beigel, F.; Sun, Y.; Kövilein, J.; Wang, J.; Kuhlmann, T.; Flierl-Hecht, A.; Haller, D.; Hohlfeld, R. et al.; Baranzini, S. E.; Wekerle, H.; Peters, A.: Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice - An unbiased functional study. Proceedings of the National Academy of Sciences of the United States of America 122 (18), e2419689122 (2025)
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2023
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Bauer, I. J.; Fang, P.; Lämmle, K. F.; Tyystjärvi, S.; Alterauge, D.; Baumjohann, D.; Yoon, H.; Korn, T.; Wekerle, H.; Kawakami, N.: Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging. Proceedings of the National Academy of Sciences of the United States of America 120 (30), e2302697120 (2023)
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Thomann, A. S.; McQuade, C. A.; Pinjusic, K.; Kolz, A.; Schmitz, R.; Kitamura, D.; Wekerle, H.; Peters, A.: A B cell–driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 120 (47), e2300733120 (2023)
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2019
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Cohen, I. R.; Wekerle, H.: Avraham Ben-Nun - Pioneer, fighter, friend. European Journal of Immunology 49 (4), S. 521 - 522 (2019)
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Enzmann, G.; Adelfio, R.; Godel, A.; Jahromi, N. H.; Tietz, S.; Burgener, S. S.; Deutsch, U.; Wekerle, H.; Benarafa, C.; Engelhardt, B.: The genetic background of mice influences the effects of cigarette smoke on onset and severity of experimental autoimmune encephalomyelitis. International Journal of Molecular Sciences 20 (6), 1433 (2019)
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publisher-version
Zeitschriftenartikel
Peters, A.; Wekerle, H.: Autoimmune diabetes mellitus and the leaky gut. Proceedings of the National Academy of Sciences of the United States of America 116 (30), S. 14788 - 14790 (2019)
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Zeitschriftenartikel
Wekerle, H.: Secondary progressive multiple sclerosis and the gut-brain axis. Brain 142, S. 838 - 840 (2019)
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2018
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Wekerle, H.: Gut molecules control brain inflammation. Nature 557 (7707), S. 642 - 643 (2018)
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2017
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Berer, K.; Gerdes, L. A.; Cekanaviciute, E.; Jia, X.; Xiao, L.; Xia, Z.; Liu, C.; Klotz, L.; Stauffer, U.; Baranzini, S. E. et al.; Kuempfel, T.; Hohlfeld, R.; Krishnamoorthy, G.; Wekerle, H.: Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proceedings of the National Academy of Sciences of the United States of America 114 (40), S. 10719 - 10724 (2017)
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publisher-version
supplementary-material
Zeitschriftenartikel
Kyratsous, N. I.; Bauer, I. J.; Zhang, G.; Pesic, M.; Bartholomäus, I.; Mues, M.; Fang, P.; Woerner, M.; Everts, S.; Ellwart, J. W. et al.; Watt, J. M.; Potter, B. V. L.; Hohlfeld, R.; Wekerle, H.; Kawakami, N.: Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America 114 (31), S. E6381 - E6389 (2017)
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Zeitschriftenartikel
Wekerle, H.: Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers. Trends in Immunology 38 (7), S. 483 - 497 (2017)
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Zeitschriftenartikel
Wekerle, H.: B cells in multiple sclerosis. Autoimmunity 50 (1), S. 57 - 60 (2017)
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Zeitschriftenartikel
Wekerle, H.: Nature, nurture, and microbes: The development of multiple sclerosis. Acta Neurologica Scandinavica 136 (Suppl. 201), S. 22 - 25 (2017)
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2016
Zeitschriftenartikel
Braendle, S. M.; Obermeier, B.; Senel, M.; Bruder, J.; Mentele, R.; Khademi, M.; Olsson, T.; Tumani, H.; Kristoferitsch, W.; Lottspeich, F. et al.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proceedings of the National Academy of Sciences of the United States of America 113 (28), S. 7864 - 7869 (2016)
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Hohlfeld, R.; Dornmair, K.; Meinl, E.; Wekerle, H.: The search for the target antigens of multiple sclerosis, part 1: Autoreactive CD4+T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurology 15 (2), S. 198 - 209 (2016)
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Hohlfeld, R.; Dornmair, K.; Meinl, E.; Wekerle, H.: The search for the target antigens of multiple sclerosis, part 2: CD8+T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurology 15 (3), S. 317 - 331 (2016)
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Wekerle, H.: The gut-brain connection: Triggering of brain autoimmune disease by commensal gut bacteria. Rheumatology 55, S. 68 - 75 (2016)
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2015
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Held, K.; Bhonsle-Deeng, L.; Siewert, K.; Sato, W.; Beltran, E.; Schmidt, S.; Ruhl, G.; Ng, J. K. M.; Engerer, P.; Moser, M. et al.; Klinkert, W. E. F.; Babbe, H.; Misgeld, T.; Wekerle, H.; Laplaud, D.-A.; Hohlfeld, R.; Dornmair, K.: αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurology Neuroimmunology & Neuroinflammation 2 (4), e107 (2015)
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Hoffmann, F. S.; Kuhn, P.-H.; Laurent, S. A.; Hauck, S. M.; Berer, K.; Wendlinger, S. A.; Krumbholz, M.; Khademi, M.; Olsson, T.; Dreyling, M. et al.; Pfister, H.-W.; Alexander, T.; Hiepe, F.; Kuempfel, T.; Crawford, H. C.; Wekerle, H.; Hohlfeld, R.; Lichtenthaler, S. F.; Meinl, E.: The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Journal of Immunology 194 (2), S. 542 - 552 (2015)
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Hohlfeld, R.; Wekerle, H.: Multiple sclerosis and microbiota. From genome to metagenome? Nervenarzt 86 (8), S. 925 - 933 (2015)
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Laurent, S. A.; Hoffmann, F. S.; Kuhn, P.-H.; Cheng, Q.; Chu, Y.; Schmidt-Supprian, M.; Hauck, S. M.; Schuh, E.; Krumbholz, M.; Rübsamen, H. et al.; Wanngren, J.; Khademi, M.; Olsson, T.; Alexander, T.; Hiepe, F.; Pfister, H.-W.; Weber, F.; Jenne, D. E.; Wekerle, H.; Hohlfeld, R.; Lichtenthaler, S. F.; Meinl, E.: γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nature Communications 6, 7333 (2015)
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Nicol, B.; Salou, M.; Laplaud, D.-A.; Wekerle, H.: The autoimmune concept of multiple sclerosis. Presse médicale & Quarterly medical review. Special Issue: Multiple sclerosis 44 (4, Part 2), S. e103 - e112 (2015)
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Wekerle, H.: Vaccination and narcolepsy: Immune link found? Science translational medicine: Integrating medicine and science 7 (294), 294fs27 (2015)
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Wekerle, H.: Nature plus Nurture: The triggering of multiple sclerosis. Swiss Medical Weekly 145, w14189 (2015)
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2014
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Ben-Nun, A.; Kaushansky, N.; Kawakami, N.; Krishnamoorthy, G.; Berer, K.; Liblau, R.; Hohlfeld, R.; Wekerle, H.: From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. Journal of Autoimmunity 54, S. 33 - 50 (2014)
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Zeitschriftenartikel
Koutrolos, M.; Berer, K.; Kawakami, N.; Wekerle, H.; Krishnamoorthy, G.: Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathologica Communications 2, 163 (2014)
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Mohan, H.; Friese, A.; Albrecht, S.; Krumbholz, M.; Elliott, C. L.; Arthur, A.; Menon, R.; Farina, C.; Junker, A.; Stadelmann, C. et al.; Barnett, S. C.; Huitinga, I.; Wekerle, H.; Hohlfeld, R.; Lassmann, H.; Kuhlmann, T.; Linington, C.; Meinl, E.: Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications 2, 168 (2014)
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2013
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Mayer, M. C.; Breithaupt, C.; Reindl, M.; Schanda, K.; Rostasy, K.; Berger, T.; Dale, R. C.; Brilot, F.; Olsson, T.; Jenne, D. E. et al.; Proebstel, A.-K.; Dornmair, K.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.: Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. Journal of Immunology 191 (7), S. 3594 - 3604 (2013)
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Molnarfi, N.; Schulze-Topphoff, U.; Weber, M. S.; Patarroyo, J. C.; Prod'homme, T.; Varrin-Doyer, M.; Shetty, A.; Linington, C.; Slavin, A. J.; Hidalgo, J. et al.; Jenne, D. E.; Wekerle, H.; Sobel, R. A.; Bernard, C. C. A.; Shlomchik, M. J.; Zamvil, S. S.: MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. Journal of Experimental Medicine 210 (13), S. 2921 - 2937 (2013)
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Mues, M.; Bartholomäus, I.; Thestrup, T.; Griesbeck, O.; Wekerle, H.; Kawakami, N.; Krishnamoorthy, G.: Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nature Medicine 19 (6), S. 778 - 783 (2013)
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Neumann, H.; Wekerle, H.: Brain microglia: Watchdogs with pedigree. Nature Neuroscience 16 (3), S. 253 - 255 (2013)
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Pesic, M.; Bartholomäus, I.; Kyratsous, N. I.; Heissmeyer, V.; Wekerle, H.; Kawakami, N.: 2-photon imaging of phagocyte-mediated T cell activation in the CNS. The Journal of Clinical Investigation 123 (3), S. 1192 - 1201 (2013)
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Pohl, M.; Kawakami, N.; Kitic, M.; Bauer, J.; Martins, R.; Fischer, M.-T.; Machado-Santos, J.; Mader, S.; Ellwart, J. W.; Misu, T. et al.; Fujihara, K.; Wekerle, H.; Reindl, M.; Lassmann, H.; Bradl, M.: T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathologica Communications 1, 85 (2013)
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Wekerle, H.: Tissue hypoxia in autoimmune brain disease: A Columbian discovery? Annals of Neurology 74 (6), S. 765 - 767 (2013)
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Wekerle, H.; Berer, K.; Krishnamoorthy, G.: Remote control - triggering of brain autoimmune disease in the gut. Current Opinion in Immunology 25 (6), S. 683 - 689 (2013)
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Wekerle, H.; Meinl, E.: Multiple sclerosis: An old drug plays a new trick. Nature 502 (7471), S. 314 - 315 (2013)
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2012
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Hohlfeld, R.; Wekerle, H.: β-Amyloid: Enemy or remedy? Science translational medicine: Integrating medicine and science 4 (145), 145fs24 (2012)
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Odoardi, F.; Sie, C.; Streyl, K.; Ulaganathan, V. K.; Schlaeger, C.; Lodygin, D.; Heckelsmiller, K.; Nietfeld, W.; Ellwart, J.; Klinkert, W. E. F. et al.; Lottaz, C.; Nosov, M.; Brinkmann, V.; Spang, R.; Lehrach, H.; Vingron, M.; Wekerle, H.; Fluegel-Koch, C.; Fluegel, A.: T cells become licensed in the lung to enter the central nervous system. Nature 488 (7413), S. 675 - 679 (2012)
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Siewert, K.; Malotka, J.; Kawakami, N.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Unbiased identification of target antigens of CD8(+) T cells with combinatorial libraries coding for short peptides. Nature Medicine 18 (5), S. 824 - 828 (2012)
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Wekerle, H.; Fluegel, A.; Fugger, L.; Schett, G.; Serreze, D.: Autoimmunity's next top models. Nature Medicine 18 (1), S. 66 - 70 (2012)
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Wekerle, H.; Krishnamoorthy, G.: Brain Autoimmunity: The CD8 Question(s). Immunity 37 (1), S. 8 - 10 (2012)
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2011
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Berer, K.; Mues, M.; Koutrolos, M.; Al Rasbi, Z.; Boziki, M.; Johner, C.; Wekerle, H.; Krishnamoorthy, G.: Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479 (7374), S. 538 - 541 (2011)
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Berer, K.; Wekerle, H.; Krishnamoorthy, G.: B cells in spontaneous autoimmune diseases of the central nervous system. Molecular Immunology 48 (11), S. 1332 - 1337 (2011)
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Obermeier, B.; Lovato, L.; Bruck, W.; Forne, I.; Imhof, A.; Mentele, R.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H. et al.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology 233 (1-2), S. 245 - 248 (2011)
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Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), S. 580 - 588 (2011)
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2010
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Domingues, H. S.; Mues, M.; Lassmann, H.; Wekerle, H.; Krishnamoorthy, G.: Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One 5 (11), e15531 (2010)
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Mohan, H.; Krumbholz, M.; Sharma, R.; Eisele, S.; Junker, A.; Sixt, M.; Newcombe, J.; Wekerle, H.; Hohlfeld, R.; Lassmann, H. et al.; Meinl, E.: Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology 20 (5), S. 966 - 975 (2010)
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Wekerle, H.; Hohlfeld, R.: Beneficial brain autoimmunity? Brain 133, S. 2182 - 2184 (2010)
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Wekerle, H.; Hohlfeld, R.: Molecular oracles for multiple sclerosis therapy. Nature Medicine 16 (4), S. 376 - 377 (2010)
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