Publications of Klaus Dornmair

Bruder, J.; Siewert, K.; Obermeier, B.; Malotka, J.; Scheinert, P.; Kellermann, J.; Ueda, T.; Hohlfeld, R.; Dornmair, K.: Target specificity of an autoreactive pathogenic human gamma delta-T cell receptor in myositis. The Journal of Biological Chemistry 287 (25), pp. 20986 - 20995 (2012)

Held, K.; Eiglmeier, I.; Himmelein, S.; Sinicina, I.; Brandt, T.; Theil, D.; Dornmair, K.; Derfuss, T.: Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia. Journal of NeuroVirology 18 (1), pp. 62 - 68 (2012)

Kim, S.-M.; Bhonsle, L.; Besgen, P.; Nickel, J.; Backes, A.; Held, K.; Vollmer, S.; Dornmair, K.; Prinz, J. C.: Analysis of the paired TCR α- and β-chains of single human T cells. PLoS One 7 (5), e37338 (2012)

Ng, J. K. M.; Malotka, J.; Kawakami, N.; Derfuss, T.; Khademi, M.; Olsson, T.; Linington, C.; Odaka, M.; Tackenberg, B.; Pruess, H. et al.; Schwab, J. M.; Harms, L.; Harms, H.; Sommer, C.; Rasband, M. N.; Eshed-Eisenbach, Y.; Peles, E.; Hohlfeld, R.; Yuki, N.; Dornmair, K.; Meinl, E.: Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79 (23), pp. 2241 - 2248 (2012)

Siewert, K.; Malotka, J.; Kawakami, N.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Unbiased identification of target antigens of CD8(+) T cells with combinatorial libraries coding for short peptides. Nature Medicine 18 (5), pp. 824 - 828 (2012)

Held, K.; Junker, A.; Dornmair, K.; Meinl, E.; Sinicina, I.; Brandt, T.; Theil, D.; Derfuss, T.: Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. Journal of Virology 85 (19), pp. 9680 - 9685 (2011)

Ivanidze, J.; Hoffmann, R.; Lochmueller, H.; Engel, A. G.; Hohlfeld, R.; Dornmair, K.: Inclusion body myositis laser microdissection reveals differential up-regulation of IFN-gamma signaling cascade in attacked versus nonattacked myofibers. American Journal of Pathology 179 (3), pp. 1347 - 1359 (2011)

Obermeier, B.; Lovato, L.; Bruck, W.; Forne, I.; Imhof, A.; Mentele, R.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H. et al.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology 233 (1-2), pp. 245 - 248 (2011)

Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), pp. 580 - 588 (2011)

Schuster, F. R.; Hubner, B.; Fuehrer, M.; Eckermann, O.; Gombert, M.; Dornmair, K.; Binder, V.; Reuther, S.; Krell, P.; Keller, T. et al.; Borkhardt, A.: Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal 1, e8 (2011)

Cordiglieri, C.; Odoardi, F.; Zhang, B.; Nebel, M.; Kawakami, N.; Klinkert, W. E. F.; Lodygin, D.; Luhder, F.; Breunig, E.; Schild, D. et al.; Ulaganathan, V. K.; Dornmair, K.; Dammermann, W.; Potter, B. V. L.; Guse, A. H.; Flügel, A.: Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133, pp. 1930 - 1943 (2010)

Dammermann, W.; Zhang, B.; Nebel, M.; Cordiglieri, C.; Odoardi, F.; Kirchberger, T.; Kawakami, N.; Dowden, J.; Schmid, F.; Dornmair, K. et al.; Hohenegger, M.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America 106 (26), pp. 10678 - 10683 (2009)

Dornmair, K.; Meinl, E.; Hohlfeld, R.: Novel approaches for identifying target antigens of autoreactive human B and T cells. Seminars in Immunopathology 31 (4), pp. 467 - 477 (2009)

Krishnamoorthy, G.; Saxena, A.; Mars, L. T.; Domingues, H. S.; Ben-Nun, A.; Lassmann, H.; Dornmair, K.; Mentele, R.; Kurschus, F. C.; Liblau, R. S. et al.; Wekerle, H.: Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nature Medicine 15 (6), pp. 626 - 632 (2009)

Lahl, K.; Mayer, C. T.; Bopp, T.; Huehn, J.; Loddenkemper, C.; Eberl, G.; Wirnsberger, G.; Dornmair, K.; Geffers, R.; Schmitt, E. et al.; Buer, J.; Sparwasser, T.: Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice. Journal of Immunology 183 (9), pp. 5662 - 5672 (2009)

Pellkofer, H. L.; Voltz, R.; Goebels, N.; Hohlfeld, R.; Dornmair, K.: Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue. Archives of Neurology 66 (5), pp. 655 - 658 (2009)

Schwab, N.; Bien, C.G.; Waschbisch, A.; Becker, A.; Vince, G.H.; Dornmair, K.; Wiendl, H.: CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132 (5), pp. 1236 - 1246 (2009)

Deininger, K.; Eder, M.; Kramer, E. R.; Zieglgänsberger, W.; Dodt, H. U.; Dornmair, K.; Colicelli, J.; Klein, R.: The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proceedings of the National Academy of Sciences of the United States of America 105 (34), pp. 12539 - 12544 (2008)

Hohlfeld, R.; Meinl, E.; Dornmair, K.: B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. Journal of Neurological Sciences 274 (1-2), pp. 5 - 8 (2008)

Obermeier, B.; Malotka, J.; Dornmair, K.; Mentele, R.: Analysis of patient-specific immunoglobulin proteomes and transcriptomes by PCR cloning and mass spectometry. (2008)

Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), pp. 688 - 693 (2008)

Derfuss, T.; Segerer, S.; Herberger, S.; Sinicina, I.; Hufner, K.; Ebelt, K.; Knaus, H. G.; Steiner, I.; Meinl, E.; Dornmair, K. et al.; Arbusow, V.; Strupp, M.; Brandt, T.; Theil, D.: Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia. Brain Pathology 17 (4), pp. 389 - 398 (2007)

Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), pp. 261 - 275 (2007)

Hohlfeld, R.; Dornmair, K.: Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69 (21), pp. 1966 - 1967 (2007)

Junker, A.; Ivanidze, J.; Malotka, J.; Eiglmeier, I.; Lassmann, H.; Wekerle, H.; Meinl, E.; Hohlfeld, R.; Dornmair, K.: Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130, pp. 2789 - 2799 (2007)

Leder, C.; Schwab, N.; Ip, C. W.; Kroner, A.; Nave, K. A.; Dornmair, K.; Martini, R.; Wiendl, H.: Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Molecular and Cellular Neuroscience 36 (3), pp. 416 - 424 (2007)

Seitz, S.; Schneider, C. K.; Malotka, J.; Nong, X.; Engel, A. G.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of human inflammatory tissues. Proceedings of the National Academy of Sciences of the United States of America 103 (32), pp. 12057 - 12062 (2006)

Dornmair, K.; Schneider, C. K.; Malotka, J.; Dechant, G.; Wiendl, H.; Hohlfeld, R.: Antigen recognition properties of a V gamma LW delta 2-T-cell receptor from a rare variant of polymyositis. Journal of Neuroimmunology 152 (1-2), pp. 168 - 175 (2004)

Kurschus, F. C.; Kleinschmidt, M.; Fellows, E.; Dornmair, K.; Rudolph, R.; Lilie, H.; Jenne, D. E.: Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Letters 562 (1-3), pp. 87 - 92 (2004)

Skulina, C.; Schmidt, S.; Dornmair, K.; Babbe, H.; Roers, A.; Rajewsky, K.; Wekerle, H.; Hohlfeld, R.; Goebels, N.: Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America 101 (8), pp. 2428 - 2433 (2004)

Dornmair, K.; Goebels, N.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.: T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. American Journal of Pathology 163 (4), pp. 1215 - 1226 (2003)

Hofbauer, M.; Wiesener, S.; Babbe, H.; Roers, A.; Wekerle, H.; Dornmair, K.; Goebels, N.: Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proceedings of the National Academy of Sciences of the United States of America 100 (7), pp. 4090 - 4095 (2003)

Wiendl, H.; Malotka, J.; Holzwarth, B.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology 169 (1), pp. 515 - 521 (2002)

Bradl, M.; Dornmair, K.; Hohlfeld, R.: New tools for investigating the immunopathogenesis of MS: Principles and applications. In: Multiple Sclerosis: A Comprehensive Text, pp. 284 - 299 (Eds. Raine, C. S.; McFarland, H. F.; Hohlfeld, R.). Saunders, Elsevier, Edinburgh (2008)

Dornmair, K.: Funktionelle Charakterisierung von autoaggressiven Lymphozyten aus Biopsieproben. Habilitation, Ludwig-Maximilians-Universität, München (2010)