Publications of the emeritus-department "Neuroimmunology"

Andrade, F.; Fellows, E.; Jenne, D. E.; Rosen, A.; Young, C. S.: Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. The EMBO Journal 26 (8), pp. 2148 - 2157 (2007)

Derfuss, T.; Segerer, S.; Herberger, S.; Sinicina, I.; Hufner, K.; Ebelt, K.; Knaus, H. G.; Steiner, I.; Meinl, E.; Dornmair, K. et al.; Arbusow, V.; Strupp, M.; Brandt, T.; Theil, D.: Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia. Brain Pathology 17 (4), pp. 389 - 398 (2007)

Dorn, T.; Kuhn, U.; Bungartz, G.; Stiller, S.; Bauer, M.; Ellwart, J.; Peters, T.; Scharffetter-Kochanek, K.; Semmrich, M.; Laschinger, M. et al.; Holzmann, B.; Klinkert, W. E. F.; Straten, P. T.; Kollgaard, T.; Sixt, M.; Brakebusch, C.: RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood 109 (6), pp. 2346 - 2355 (2007)

Dorn, T.; Kuhn, U.; Bungartz, G.; Stiller, S.; Bauer, M.; Ellwart, J.; Peters, T.; Scharffetter-Kochanek, K.; Semmrich, M.; Laschinger, M. et al.; Holzmann, B.; Klinkert, W. E. F.; Straten, P. T.; Kollgaard, T.; Sixt, M.; Brakebusch, C.: RhoH and T cell development. RhoH is important for mouse thymocyte selection and T-cell receptor signaling. Blood 6, pp. 2346 - 2355 (2007)

Farina, C.; Aloisi, F.; Meinl, E.: Astrocytes are active players in cerebral innate immunity. Trends in Immunology 28 (3), pp. 138 - 145 (2007)

Fellows, E.; Gil-Parrado, S.; Jenne, D. E.; Kurschus, F. C.: Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. Blood 110 (2), pp. 544 - 552 (2007)

Flügel, A.; Odoardi, F.; Nosov, M.; Kawakami, N.: Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. Journal of Neuroimmunology 191 (1-2), pp. 86 - 97 (2007)

Gong, N.; Pleyer, U.; Vogt, K.; Anegon, I.; Flügel, A.; Volk, H.-D.; Ritter, T.: Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival. Investigative Ophthalmology and Visual Science 48 (3), pp. 1043 - 1052 (2007)

Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), pp. 261 - 275 (2007)

Hajjar, E.; Korkmaz, B.; Reuter, N.: Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase. FEBS Letters 581 (29), pp. 5685 - 5690 (2007)

Hoffmann, L. A.; Krumbholz, M.; Faber, H.; Kuempfel, T.; Starck, M.; Pöllmann, W.; Meinl, E.; Hohlfeld, R.: Multiple sclerosis: Relating MxA transcription to anti-interferon-β-neutralizing antibodies. Neurology 68 (12), pp. 958 - 959 (2007)

Hohlfeld, R.; Dornmair, K.: Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69 (21), pp. 1966 - 1967 (2007)

Hohlfeld, R.; Kerschensteiner, M.; Meinl, E.: Dual role of inflammation in CNS disease. Neurology 68 (3), pp. 58 - 63 (2007)

Hüfner, K.; Arbusow, V.; Himmelein, S.; Derfuss, T.; Sinicina, I.; Strupp, M.; Brandt, T.; Theil, D.: The prevalence of human herpesvirus 6 in human sensory ganglia and its co-occurrence with alpha-herpesvirus. Journal of Neurovirology 13 (5), pp. 462 - 467 (2007)

Jarius, S.; Eichhorn, P.; Albert, M. H.; Wagenpfeil, S.; Wick, M.; Belohradsky, B. H.; Hohlfeld, R.; Jenne, D. E.; Voltz, R.: Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFα-dependent and Fc-receptor-independent way. Blood 109 (10), pp. 4376 - 4382 (2007)

Jarius, S.; Franciotta, D.; Bergamaschi, R.; Wright, H.; Littleton, E.; Palace, J.; Hohlfeld, R.; Vincent, A.: NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 68 (13), pp. 1076 - 1077 (2007)

Jarius, S.; Friedemann, P.; Franciotta, D.; Aktas, O.; Hohlfeld, R.; Zipp, F.; Vincent, A.: Revised diagnostic criteria for neuromyelitis optica-incorporation of NMO-IgG status. Nature Clinical Practise Neurology 5, pp. 2774 - 2783 (2007)

Jenne, D. E.; Aries, P. M.; Einwächter, S.; Akkad, A. D.; Wieczorek, S.; Lamprecht, P.; Gross, W. L.: The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis. Annals of the Rheumatic Diseases 66 (9), pp. 1266 - 1267 (2007)

Junker, A.; Ivanidze, J.; Malotka, J.; Eiglmeier, I.; Lassmann, H.; Wekerle, H.; Meinl, E.; Hohlfeld, R.; Dornmair, K.: Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130, pp. 2789 - 2799 (2007)

Kessenbrock, K.; Raijmakers, R.; Fritzler, M. J.; Mahler, M.: Synthetic peptides: The future of patient management in systemic rheumatic diseases? Current Medicinal Chemistry 14 (26), pp. 2831 - 2838 (2007)

Kramer, E. R.; Aron, L.; Ramakers, G. M. J.; Seitz, S.; Zhuang, X. X.; Beyer, K.; Smidt, M. P.; Klein, R.: Absence of ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biology 5 (3), e39, pp. 616 - 628 (2007)

Krishnamoorthy, G.; Holz, A.; Wekerle, H.: Experimental models of spontaneous in the central nervous system. Journal of Molecular Medicine-JMM 85 (11), pp. 1161 - 1173 (2007)

Krumbholz, M.; Pellkofer, H.; Gold, R.; Hoffmann, L.; Hohlfeld, R.; Kümpfel, T.: Delayed allergic reaction to natalizumab associated with early formation of neutralizing antibodies. Archives of Neurology 64, pp. 1331 - 1333 (2007)

Krumbholz, M.; Theil, D.; Steinmeyer, F.; Cepok, S.; Hemmer, B.; Hofbauer, M.; Farina, C.; Derfuss, T.; Junker, A.; Arzberger, T. et al.; Sinicina, I.; Hartle, C.; Newcombe, J.; Hohlfeld, R.; Meinl, E.: CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. Journal of Neuroimmunology 190 (1-2), pp. 72 - 79 (2007)

Leder, C.; Schwab, N.; Ip, C. W.; Kroner, A.; Nave, K. A.; Dornmair, K.; Martini, R.; Wiendl, H.: Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Molecular and Cellular Neuroscience 36 (3), pp. 416 - 424 (2007)

Lisak, R. P.; Hohlfeld, R.: Neurodegeneration, neuroprotection, glial cells, and myelin in multiple sclerosis. Neurology 68 (Suppl. 3), p. S1 - S1 (2007)

Lyakhovich, A.; Canals, F.; Nosov, M.; Surralles, J.: A DIGE-based approach to study interacting proteins. Journal of Biochemical and Biophysical Methods 70 (4), pp. 693 - 695 (2007)

Mathey, E. K.; Derfuss, T.; Storch, M. K.; Williams, K. R.; Hales, K.; Woolley, D. R.; Al-Hayani, A.; Davies, S. N.; Rasband, M. N.; Olsson, T. et al.; Moldenhauer, A.; Velhin, S.; Hohlfeld, R.; Meinl, E.; Linington, C.: Neurofascin as a novel target for autoantibody-mediated axonal injury. Journal of Experimental Medicine 204 (10), pp. 2363 - 2372 (2007)

Odoardi, F.; Kawakami, N.; Klinkert, W. E. F.; Wekerle, H.; Flügel, A.: Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America 104 (47), pp. 18625 - 18630 (2007)

Odoardi, F.; Kawakami, N.; Li, Z. X.; Cordiglieri, C.; Streyl, K.; Nosov, M.; Klinkert, W. E. F.; Ellwart, J. W.; Bauer, J.; Lassmann, H. et al.; Wekerle, H.; Flügel, A.: Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 104 (3), pp. 920 - 925 (2007)

Paul, F.; Jarius, S.; Aktas, O.; Bluthner, M.; Bauer, O.; Appelhans, H.; Franciotta, D.; Bergamaschi, R.; Littleton, E.; Palace, J. et al.; Seelig, H.-P.; Hohlfeld, R.; Vincent, A.; Zipp, F.: Antibody to aquaporin 4 in the diagnosis of neuomyelitis optica. PLoS Medicine 4 (4), e133, pp. 0669 - 0674 (2007)

Stich, O.; Jarius, S.; Kleer, B.; Rasiah, C.; Voltz, R.; Rauer, S.: Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes. Journal of Neuroimmunology 183 (1-2), pp. 220 - 224 (2007)

Weber, M. S.; Hohlfeld, R.; Zamvil, S. S.: Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics 4 (4), pp. 647 - 653 (2007)

Wekerle, H.: L'énigme de l'entrée des lymphocytes T auto-immuns dans les tissus nerveux centraux et de leur attaque contre les structures de myéline. Comptes Rendus Biologies 330 (1), pp. 1 - 12 (2007)

Wekerle, H.; Flügel, A.: Demyelinating diseases: Immunological mechanisms in the pathogenesis of multiple Sclerosis. In: Molecular Neurology, pp. 475 - 497 (Ed. Waxman, S. G.). Elsevier (2007)

Fellows, E.: Granzyme H: A novel cell-death inducing serine protease: Granzyme H induced cell death. Dissertation, Ludwig-Maximilians-Universität, München (2007)

Krishnamoorthy, G.: Devic mouse: A sponeaneous double-transgenic mouse model of human opticospinal multiple sclerosis and autoimmune T- B cell cooperation. Dissertation, Ludwig-Maximilians-Universität, München (2007)

Pöllinger, B.: Die RR-Maus - Ein T-Zell-Rezeptor-transgenes Mausmodell für spontane schubförmig-remittierende Multiple Sklerose. Dissertation, Ludwig-Maximilians-Universität, München (2007)

Seitz, S.: Identifikation und Charakterisierung von autoreaktiven humanen T-Zell-Rezeptor Molekülen. Dissertation, Julius-Maximilians-Universität, Würzburg (2007)